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Ridhi Sidhi Granites Granites

Granite is made up of interlocking mineral crystals, the most common being feldspar and quartz. But an array of other minerals can be included, and these make each piece of granite unique. Feldspar is the white mineral you see in granite; the light gray veins are quartz; and the black is typically mica.

Rajesh Agraval

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SOMARAJU Y

Discover the perfect balance of convenience and freshness with our semi-husked coconuts. Easier to handle, these coconuts retain their natural goodness, making them ideal for your culinary adventures. Whether you're crafting refreshing drinks, cooking delectable dishes, or indulging in healthy snacks, our semi-husked coconuts are your go-to choice for authentic taste and rich nutrients. TO ORDER:- +91 9885803631 info@worldclasstraders.co.in

SOMARAJU Y

Discover the perfect balance of convenience and freshness with our semi-husked coconuts. Easier to handle, these coconuts retain their natural goodness, making them ideal for your culinary adventures. Whether you're crafting refreshing drinks, cooking delectable dishes, or indulging in healthy snacks, our semi-husked coconuts are your go-to choice for authentic taste and rich nutrients. TO ORDER:- +91 9885803631 info@worldclasstraders.co.in

SOMARAJU Y

Discover the perfect balance of convenience and freshness with our semi-husked coconuts. Easier to handle, these coconuts retain their natural goodness, making them ideal for your culinary adventures. Whether you're crafting refreshing drinks, cooking delectable dishes, or indulging in healthy snacks, our semi-husked coconuts are your go-to choice for authentic taste and rich nutrients. TO ORDER:- +91 9885803631 info@worldclasstraders.co.in

Sayan Sahs

Santoshi hardware

SUKANTA OVERSEAS

Complex redox reactions occur in the human body. Consequently, free radical formation is counteracted by specific endogenous enzymes, such as superoxide dismutase, catalase, and glutathione peroxidase, and by exogenous antioxidants from plant sources [1, 2]. Citrus fruits contain many pharmaceutically important bioactive compounds that are the main contributors to their inherent antioxidant properties [3]. Citrus macroptera var. annamensis (family, Rutaceae) is locally known as “Satkara” in Bengali and “Wild orange” in English [4]. The semiwild species is native to regions of Malesia and Melanesia [5]. The C. macroptera plant is grown in the yard of most homesteads and hill tracts of the Sylhet division of Bangladesh. The fruit is typically used during cooking and for pickle preparation and is popular for its medicinal purposes in Assam, India [6]. It is also used by locals in Northeast India as medicine for stomach pain and alimentary disorders [7]. The C. macroptera fruit has significant cytotoxic, antimicrobial [8], antihypertensive, antipyretic, and appetite stimulant potentials [9, 10]. Additionally, significant hypoglycemic and neuropharmacological effects were confirmed in a rat model [11, 12]. The antioxidant constituents in the C. macroptera fruit include phenolics, flavonoids, tannins, ascorbic acid, and proteins, and significant radical scavenging activity was confirmed by an in vitro study [13]. Therefore, this fruit is postulated to play a therapeutic role in reducing the risk of some forms of fatal oxidative stress disorders, such as liver and kidney dysfunction, cardiovascular disease, and stroke [8, 14, 15]. The liver is a vital ***** involved in the detoxification and elimination of toxic substances. The liver is often distressed by a large number of environmental pollutants and drugs, all of which burden, damage, or weaken it, ultimately leading to diseases such as hepatitis and cirrhosis [16]. Drug-induced toxicity of vital organs, including the liver and kidney, is frequently observed worldwide [17, 18]. Paracetamol (acetaminophen or N-acetyl-p-aminophenol; APAP) is a widely used over-the-counter analgesic and antipyretic drug [19]; APAP overdose can cause severe hepatocyte injury. APAP-induced hepatotoxicity is attributed to its reactive metabolite N-acetyl-p-benzoquinone imine (NAPQI), which is generated through cytochrome p450 and causes oxidative stress due to its ability to covalently react with proteins and nucleic acids and to deplete glutathione (GSH) [20–22]. There is also subtle evidence that APAP can cause harmful effects to the kidneys, which are important for drug elimination [23]. Interestingly, there is a plausible metabolic and pathophysiological link between the kidneys and the liver [24]. Both hepatotoxicity and nephrotoxicity are potential complications of APAP overdose, making the assessment of APAP-related toxicity indispensable [25]. There is particular interest in APAP-induced toxicity due to its overuse in Bangladesh, where no strong monitoring system is in place to regulate the utilization of over-the-counter drugs, such as APAP. Therefore, APAP-induced toxicity is a concern that affects many people. Searching for novel medicinal plants with greater safety and efficacy has become the primary goal of medicinal chemists. We postulate that the high antioxidant potential of C. macroptera may confer protective effects when administered. Therefore, this study was designed to investigate the pharmaceutical effects of C. macroptera against APAP-induced hepatorenal toxicity in a rat model of liver and kidney diseases.

Abhijit Mandal

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